Viablife Biotech

【Synonyms】：Ceramide3
【CAS No.】：34354-88-6
【Formula】：C36H73NO4
【Molecular Weight】：583.97
【Appearance】：White powder
Ceramide is the main lipid component of the lamellar lamellae present in the intercellular spaces of the stratum corneum. These lamellar lamellae are supposed to provide the barrier properties of the epidermis. It is generally believed that the intercellular lipid domain is composed of approximately 45-50% ceramide, 25% cholesterol, 15% free fatty acids, and 2% phytosphingosine. The presence of a lipid in the nervous tissue of the brain was first discovered in 1884 by Johann Thudichum in a publication titled "A treatise on the chemical constitution of the brain". Since its biological function is difficult to understand, the lipid was named Sphingolipid after the Sphinx in ancient Egyptian mythology by the root word "Sphingo-". Sphingolipids were later classified into three types: sphingomyelins, glycosphingolipids, and ceramides.

Ceramides are structurally heterogeneous and complex sphingolipids that differ in chain length, type and degree of hydroxylation, and degree of saturation. Ceramide is formed by covalent condensation of sphingosine and long-chain fatty acids with 12 to 30 carbon atoms. Different combinations of three sphingosine and four fatty acids are connected through amide to form different ceramides in the stratum corneum, mainly twelve categories. Ceramide NP is the most abundant and functionally important category. Ceramides play a vital role in building and maintaining the skin's water permeability barrier function. Together with other cuticle lipids, they form an ordered structur